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The Advisory Committee on Immunization Practices (ACIP) recommends that children 6 to 23 months of age be vaccinated annually against influenza.
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Sources of funding for pharmaceutical research has come under scrutiny in the last decade as academic and government sources of funding have become increasingly scarce and the pharmaceutical industry has become the main source of research dollars. But the issue of objectivity has been raised, and some have even suggested that negative studies, that is studies that show a drug in an unfavorable light, may never be published. The American Medical Association has recently tackled this issue.
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Leflunomides immunomodulatory activity derives from its action as a competitive inhibitor of the rate-limiting enzyme necessary for pyrimidine synthesis.
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Evidence suggests that Erythropoietin acts by stimulating neuroprotective pathways, including the protein kinase B cascade and the transcription factor nuclear factor-kB pathway, to activate antiapoptotic and antioxidant factors.
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The good news from the Oxford Vascular Study is that community-wide risk factor modifications and preventive treatment are worth the effort, and that further reductions in stroke incidence are possible with more widespread stroke prevention programs.
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These findings are amongst the most direct data to date that oxidative damage plays a critical role in normal human aging.
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Converging evidence implicates both protein aggregation as well as oxidative damage in mitochondrial dysfunction in Parkinsons disease pathogenesis. It is likely that these factors may interact.
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Treatment of TGA patients with antiplatelet treatment is likely warranted, particularly if there are underlying vascular risk factors.
